Treatment with rituximab and hydroxychloroquine in a patient with membranous nephropathy and diabetic nephropathy: A case report

Abstract Nephrotic syndrome (NS), which includes primary and secondary types, is one of the causes end-stage kidney disease. Common in adults include diabetic nephropathy (DN), membranous (MN), focal segmental glomerulosclerosis. About 30%–40% diabetics can develop into DN. The incidence nephrotic patients was not significantly different from that general population. Herein we present a windfall treatment rituximab combined with hydroxychloroquine patient MN A 51-year-old Chinese man, diagnosed type 2 diabetes mellitus (T2DM) 12 years ago, admitted to hospital due edema bilateral lower limbs severe proteinuria. Serology showed obvious elevation anti-phospholipase A2 receptor (anti-PLA2R) level renal biopsy concomitant After low dosage prednisone standard rituximab, patient’s proteinuria decreased; however, effect unsatisfactory elevated again 8 months. Thus, initiated, resulted diminishing albumin returning normal level. Therefore, even complicated DN, still have promising remission after being treated hydroxychloroquine.